Best-Selling Health Retail Supplement Brands & Trending Ingredients

The global health supplement market is projected to reach USD 55.19 billion by 2025, driven by increasing consumer awareness and demand for wellness products . With this growth, it’s essential to identify top-performing brands and trending ingredients that prioritize safety, efficacy, and consumer satisfaction.

Top 10 Best-Selling Health Supplement Brands in 2025

1. Thorne Research

   • Overview: Renowned for its NSF Certified for Sport seal, ensuring products are free from banned substances and contaminants.

   • Certifications: NSF Certified for Sport, cGMP.

   • Market Position: A leader in clinical-grade supplements, trusted by healthcare professionals.

2. Garden of Life

   • Overview: Offers a wide range of whole-food-based supplements with a focus on organic ingredients.

   • Certifications: USDA Organic, Non-GMO Project Verified, cGMP.

   • Market Position: Popular among consumers seeking clean-label products.

3. Pure Encapsulations

   • Overview: Specializes in hypoallergenic, research-based dietary supplements.

   • Certifications: cGMP, NSF Certified.

   • Market Position: Preferred by individuals with sensitivities and allergies.

4. NOW Foods

   • Overview: Provides a broad spectrum of affordable supplements without compromising quality.

   • Certifications: cGMP, Non-GMO Project Verified.

   • Market Position: A staple in both retail and online markets.

5. Life Extension

   • Overview: Focuses on science-based supplements aimed at longevity and age-related health.

   • Certifications: cGMP, NSF Certified.

   • Market Position: Known for cutting-edge formulations and research.

6. Nature Made

   • Overview: Offers a wide range of vitamins and supplements, widely available in pharmacies.

   • Certifications: USP Verified, cGMP.

   • Market Position: A trusted brand among consumers seeking reliable supplements.

7. HUM Nutrition

   • Overview: Provides beauty and wellness supplements with a focus on skin, hair, and mood.

   • Certifications: cGMP, Non-GMO.

   • Market Position: Popular among millennials and Gen Z.

8. Ritual

   • Overview: Known for its traceable ingredients and minimalist formulations.

   • Certifications: cGMP, Non-GMO.

   • Market Position: Appeals to consumers seeking transparency and simplicity.

9. Abbott Laboratories (Ensure)

   • Overview: Offers nutritional shakes and supplements, particularly for older adults and those recovering from illness.

   • Certifications: cGMP, NSF Certified.

   • Market Position: A trusted name in clinical nutrition.

10. NativePath

    • Overview: Focuses on ancestral health supplements, including collagen and berberine products.

    • Certifications: cGMP, Non-GMO.

    • Market Position: Gaining popularity for its natural and holistic approach.

Trending Supplement Ingredients in 2025

1. Berberine

   • Benefits: Supports healthy blood sugar levels and metabolic health.

   • Top Brand: NativePath’s 3-in-1 Berberine Formula is leading the market.

2. Lion’s Mane Mushroom

   • Benefits: Promotes cognitive function and nerve health.

   • Top Brand: Double Wood Supplements offers a highly rated Lion’s Mane extract.

3. Nicotinamide Mononucleotide (NMN)

   • Benefits: Supports cellular energy and longevity.

   • Top Brand: Elysium Basis is a leading NMN supplement.

4. Magnesium L-Threonate

   • Benefits: Enhances brain function and memory.

   • Top Brand: Magtein offers a highly bioavailable form of magnesium.

5. Clear Whey Protein

   • Benefits: Provides a refreshing, low-calorie protein source.

   • Top Brand: Transparent Labs offers a popular Clear Whey Isolate.

6. Collagen Peptides

   • Benefits: Supports skin elasticity, joint health, and hair growth.

   • Top Brand: Vital Proteins is a market leader in collagen supplements.

7. Probiotics (Akkermansia muciniphila)

   • Benefits: Targets gut health and metabolic function.

   • Top Brand: Elysium’s Matter supplement includes this strain.

8. Turmeric (Curcumin)

   • Benefits: Offers anti-inflammatory and antioxidant properties.

   • Top Brand: Thorne’s Curcumin Phytosome is highly bioavailable.

9. Vitamin D3 + K2

   • Benefits: Supports bone and cardiovascular health.

   • Top Brand: Life Extension’s Super K with Advanced K2 Complex is a top-rated choice.

10. Ashwagandha

    • Benefits: Helps manage stress and anxiety.

    • Top Brand: KSM-66 Ashwagandha is a potent and trusted extract.

Safety, Certifications & Market Leadership

All the brands and ingredients mentioned above adhere to stringent safety standards and certifications:

• cGMP (Current Good Manufacturing Practices): Ensures products are consistently produced and controlled according to quality standards.

• NSF Certified for Sport: Verifies that supplements are free from banned substances and contaminants.

• USP Verified: Confirms the quality, purity, and potency of supplements.

• Non-GMO Project Verified: Assures that products are made without genetically modified organisms.

These certifications are crucial for consumer trust and product efficacy.

Conclusion

In 2025, the health supplement industry continues to evolve, with brands focusing on transparency, quality, and innovative formulations. Consumers are increasingly seeking products that are not only effective but also backed by scientific research and certifications. The brands and ingredients highlighted in this article represent the forefront of this movement, offering products that meet the highest standards of safety and efficacy.

Note: Always consult with a healthcare professional before starting any new supplement regimen, especially if you have underlying health conditions or are taking other medications.

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